Maria Ferdinanda of Saxony, the second wife of Grand Duke Ferdinand III of Tuscany, was childless. It was his first wife, Louise of Naples, who gave him children and was the great-grandmother of Louise.
Thank you for correcting me Trentk80 - there were many intermarriages between the Saxons and the Habsburgs of Tuscany that I became derailed! In fact most of them seemed to produce no children but were probably the reason why the marriage was arranged in the first place, because of the previous family connections. But I note that Louise of Naples' grandmother was Maria Amalia of Saxony, so there is a Saxon connection although a bit further back.
However, the 'princess of saxony' in Cranach's painting is thought to be Elizabeth of Hesse, the future wife of Johann Duke of Saxony, who died childless. So she might not have been a Saxon either!
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