Alexei and Hemophilia

[Belochka]

Can this hemiparesis have the same symtoms as hemophilia?
AGRBear

Hi Bear,

Hemiparesis is a complication of a pre-existing condition. It is the motor weakness or paralysis seen down one side of the body. This condition is seen in a number of other pathologic conditions including stroke, encephalitis and head trauma (e.g. car accident).

Hemiparesis can be seen in patients suffering Hemophila, where there has been a spontaneous subdural (space between the skull and brain) hematoma.

In Alexei's case he did not suffer a subdural hematoma nor did he ever have a stoke. Alexei never experienced Hemiparesis.

Perhaps Mr Filatov did experience some degree of Hemiparesis following head trauma which produced his delusional imperial thoughts.

At least the family might receive some funds from the proceeds of that fictitious book.  

[missmoldavite]

I was just wondering. The word "hemophilia" covers quite a broad range of blood mutations/deletions.
Is it posssible that Alexei suffered froma rare version of familial mediterranean fever. There is a rare version that is passed only from one parent. ie mother.
Its not a version that is even listed on the websites but it does exist.

Its all so very interesting isn't it?.

[helenazar]

There is a rare version that is passed only from one parent. ie mother.

 I am not sure what you mean, as most hemophiliacs inherit this disease through the mother.

[missmoldavite]

To understand more suggest you look it up.
familial mediterranean fever. DEL M694.
its rather interesting.

[Maria_Pavlovna]

My one of my teachers Mrs. Muir told me last year

A female can get hemophilia by 1% out 99% . Very ---Very rare for Females to be Hemophiliacs if the mother is a carrier and the fahter a hemophiliac himself.

A male can get by 50% out of 50% if the mother a carrier. Unsure if the fahter is a hemophiliac.? not sure.

In my studies I'm sure that Marie was a carrier. Pity  

[otmafan]

My one of my teachers Mrs. Muir told me last year

A female can get hemophilia by 1% out 99% . Very ---Very rare for Females to be Hemophiliacs if the mother is a carrier and the fahter a hemophiliac himself.

A male can get by 50% out of 50% if the mother a carrier. Unsure if the fahter is a hemophiliac.? not sure.

In my studies I'm sure that Marie was a carrier. Pity  

You're right Mandie, a female hemophiliac is rare, there has only been a few cases. She would die at in adolescences anyway.

If the father is a hemophiliac the daughter will automatically be a carrier. The son will not be affected because the father only has a defective X gene not Y.

[Maria_Pavlovna]

What a great reply.

This answers a lot of questions all in one post.

As to his weight, well,  who knows for sure.  I was wiry as a kid and at 5'5''and  110 pounds which meant there was no fat whats-so-ever.... and Alexei at about 5'8'' would have been near death at 80 pounds,  I think.  Also,  when a sick person doesn't move around,  one doesn't lose weight  if still eating regular meals.....

Thanks.

AGRBear

PS:  Forgot to ask: "The Tobolsk episode had in fact also involved not being able to keep food down.  Alexandra Feodorovna reported that her son was 'terribly thin and yellow'."   Was this true of Alexei in June/July 1918 in  Ekaterinburg??
 

How tall was Alexei? someone said that he was taller then Nicholas?

[olga]

She would die at in adolescences anyway.

Would a female haemophiliac die during menstruation?

[helenazar]

Would a female haemophiliac die during menstruation?

That's a good question. My guess is no, because it is not the same type of bleeding, but I could be wrong...

[Forum Admin]

I may be incorrect, but isn't hemophilia stricly a male disease? I didn't think females could be hemphiliac....

[helenazar]

I may be incorrect, but isn't hemophilia stricly a male disease? I didn't think females could be hemphiliac....

FA, it's possible, if the father is a hemophiliac and the mother is a carrier... if the daughter inherits both those genes, she will be a hemophiliac. It is more common nowadays than back in the 19th century because most male hemophiliacs now live long enough to have children.

[otmafan]

Would a female haemophiliac die during menstruation?

From what I have heard, she would. It couldn't stop and she would bleed to death. There have only been a few cases, its really rare in females.

[helenazar]

From American Journal of Medicine:

Severe factor VIII and factor IX deficiency in females.

Lusher JM, McMillan CW.
A survey of 11 hemophilia centers produced data concerning 28 females with extremely low levels of factor VIII or IX coagulant activity. Ten of the 28 have hemophilia A, six have hemophilia B, and 12 have severe von Willebrand's disease. The 16 females who have severe factor VIII or factor IX deficiency as an isolated defect exemplify several of the possible genetic explanations for the occurrence of hemophilia in females. All 16 bruise excessively, and several have had recurrent hemarthroses. Three of these girls, ages five, 10 and 23 years, have evidence of chronic hemophilic arthropathy. The 12 females with severe von Willebrand's disease are either homozygous for von Willebrand's disease or severely affected heterozygotes. All 12 have mucous membrane bleeding. In addition, five of the 12 have recurrent hemarthroses and three have evidence of chronic joint disease. However, the major problem in the adult females with von Willebrand's disease has been extreme menorrhagia. One of the seven adults underwent irradiation sterilization and another had a hysterectomy because of menorrhagia. The others have been managed with anovulatory drugs or plasma infusions and EACA. Despite menorrhagia, five pregnancies and deliveries have been uneventful in three of these women.

And a link with information about females with bleeding disorders:

http://www.hemophilia.ca/en/pdf/13/Clinic_Manual_Eng.pdf

[investigator]

I have often wondered how he felt about his disease.  I mean as he grew older he must have felt depressed because he knew he could not have a normal life.  I mean he could not play like a normal teenager.  Keeping in mind that his life was going to be short because of the disease.  And he would never be Tsar.  Did he think about these things? I know that Alexandra really protected him but still a person cannot ignore all this.  Please share your opinions.

[Abby]

I think he felt hampered by it and wanted nothing else but to be able to be active like a normal child. He probably despised all the fussing that was made around him - he seemed like an independent carefree kid!

I read that he was more compassionate toward others because of his disease, and it made him appreciate suffering.