He was the second son of King William I of the Netherlands and his wife, Wilhelmine of Prussia.
Frederik married in Berlin on 21 May 1825 his first cousin Louise, daughter of Frederick William III of Prussia. They had four children:
* Wilhelmina Frederika Alexandrine Anna Louise (1828-1871), married to Charles XV of Sweden
* Willem Frederik Nicolaas Karel (The Hague, 6 July 1833 - The Hague, 1 November 1834)
* Willem Frederik Nicolaas Albert (The Hague, 22 August 1836 - The Hague, 23 January 1846)
* Wilhelmina Frederika Alexandrine Anna Louise Marie (Pauw Haus, Wassenaar, 5 July 1841 - Neuwied, 22 June 1910), married in Wassenaar on 18 July 1871 to William,
Prince of Wied (Neuwied, 22 August 1845 - Neuwied, 22 October 1907). They were parents of William, Prince of Albania.
(Not really new names...)
