so many things impacted on the outcome of the end of the monarchy that i think it is impossible to lay all the blame on alix or nicky. or in that case to label all of the problems that caused them both to be a "problem" for instance, i think to say that alix's poor health, (imo anxiety and stresss induced mostly), religious views, political views, place of birth etc, can not be blamed singly or combined for the downfall of the monarchy- likewise nicky's poor decision making, choice of consort and weak judgment cannot be blamed. so many things combined to make things the way that they were- like you say, the early death of alexander III, you may lay the blame mostly or entirely on alix or nicky, but you must consider what put them in the position that they were.
back to alix's health i wonder if anyone knows the name of it, but there is a long term sort of nervous breakdown, which the name of i can't recall, which brings about both severe anixety and depression with serious migraines, wonder if anyone knows what i'm talking about?