Because we're asking questions doesn't mean we are not going to come to the same conclusion as the doctors Forum Admin. has provided.
I think all too often some posters forget that many of us are here just to chit-chat and learn something we didn't know yesterday.
I for one know very little about hemophilia and the medical records of Alexei or who has studied what is available.
These questions caused me to think about the fact that doctors back in 1917 didn't know what we know today, so, why couldn't Alexei had a different blood disorder?
Apparently, there is a difference of opinion.
This makes a good debate.
And, I don't believe I've voiced that the doctors of today who have studied Alexei's medical records are incorrect. Why would I? I didn't know anyone had. From what I've understood none of the medical records had survived. As for photographs of Alexie's bruises, I had never heard of these either.
So, please, help those of us to learn more so we can be better informed.
Now, I'm off to read some of these articles mentioned by other posters. I am looking for the answer about Alexei having a raise temperature with his bouts of bleeding and if this is or is not a common symptom of one suffering hemophilia.
Here's just a little light reading to begin with for those who might be interested in looking into some of the alternatives:
http://www.emedicine.com/med/topic987.htm http://www.emedicine.com/med/topic979.htm http://www.nlm.nih.gov/medlineplus/ency/article/000586.htm http://www.nlm.nih.gov/medlineplus/ency/article/000571.htm http://www.nlm.nih.gov/medlineplus/ency/article/003270.htm ... and for those who aren't interested in the alternatives at all...
Here are five examples of sites devoted to haemophilia that list the symptoms of that best known of blood diseases. You're welcome to go through those lists of the known symptoms of haemophilia and tell us all exactly where you see evidence of any of Alexei's other known symptoms.. such as a rising temperature, fever, severe pallor (evidence of jaundice?), irregular heartbeat, delirium.. and of course the symptom that made Rasputin so undeservedly famous as a healer.. unexplained sudden recovery.
... and let's not forget Prince Leopold's symptom of epileptic-like seizures at the height of his most serious episodes..
http://www.emedicinehealth.com/articles/6481-3.asp http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/10115/216738.html?d=dmtHealthAZ http://www.nhsdirect.nhs.uk/en.asp?TopicID=226&AreaID=1322&LinkID=925 http://www.medic8.com/healthguide/articles/haemophilia.html http://www.irishhealth.com/?level=4&con=505#q2In fact, Hemophilia really only has one symptom... and just that one symptom alone.. the symptom of Bleeding. The only other questions to be asked are the location, the form, and the cause of the bleeding and the degree of severity. Any additional symptoms that accompany the bleeding, whether the bleeding is just a bruise or it's a life threatening hemorrhage, those additional symptoms are not the direct result of a clotting factor deficiency.
Either those additional symptoms are completely secondary to the bleeding... caused by the bleeding having made the body vulnerable to some other outside problem or infection... or the bleeding isn't caused by hemophilia at all. It's caused by some other blood disease that actually includes those additional symptoms.
In haemophilia, the bleeding itself has no direct connection to any symptoms of fever. If an excessively long bleeding episode exposes the body to infection.. then it's the infection that might cause a fever . The bleeding has nothing to do with it.
If, however, the fever and bleeding are obviously connected... with the intensity of both the bleeding and the fever clearly linked hand in hand as they noticeably increase and decrease together in severity... then it is *not* haemophilia. It's some other blood disease.
... and here's one just for those who insist on pushing the notion of X-linked inheritance to support their favourite theory..
The link below is to the Gene Map location Xq28. The highlighted point on this page is for an enzyme known as G6PD, which is short for Glucose-6-Phosphate Dehydrogenase. G6PD is one of the most common causes of haemolytic anaemia. In fact, G6PD Deficiency is the most common disease causing enzyme in humans with more than three hundred known variants....
But... Just for me.. :-) Look just a little bit closer at this same tiny section of the human gene map.. and then count five positions down from the highlighted position for G6PD... and what do you see?
http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?ORG=hum&CHR=X&maps=loc-r.morbid.gene&R1=on&query=G6PD&VERBOSE=ON&ZOOM=3 No.. Your eyes do not deceive you. There it is. The human gene map location for the AP Board's favourite gene... F8... the Factor VIII Gene.. the X-linked recessive cause of classic Haemophilia... and it's sitting almost right next door to G6PD.. one of the most common known causes of another blood disorder called Haemolytic Anaemia.
And there you have it. Only four other gene points on that gene map separating the known cause of classic haemophilia and one of the most common causese of haemolytic anaemia. Both in the same place on the long arm of the X-Chromosome and both inherited in the same fashion. Just five positions away from the F8 gene of haemophilia, G6PD, one of the most common genetic causes of haemolytic anaemia, a blood disorder that is known to be the cause of easy bruising, bleeding, and haemorrhage... as well as all those other additional symptoms of rising temperature, pallor, fever, irregular heartbeat, delirium, Leopold's epileptic-like fits at the height of his most serious episodes, and yes... even Alexei's most famous symptom of mysteriously spontaneous recovery... all of those very same symptoms that a diagnosis of haemophilia simply cannot explain.
Please see:
http://www.emedicine.com/med/topic900.htm And that's just one known cause of the platelet disorders of haemolytic anaemia that can be found on the same X-Chromosome. There's more where that one came from.
Oh... and the most common cause of excessive and irregular bleeding? An abnormally low platelet count. Not a clotting factor deficiency.
http://www.merck.com/pubs/mmanual_ha/sec3/ch49/ch49c.html So... Is anyone starting to see it yet?. Or are you all still going to keep on fighting it tooth and nail?
Anyone here who continues to doubt any of this information is totally free to take anything at all that I have posted on this thread to their closest haematologist and ask for confirmation. You don't need to go any further than the closest hospital or university medical school... and I'm not the least bit concerned about what any recognised haematolgist is going to tell you about all of this same medical information... because it has already been approved by a full medical review of their peers.
