Perhaps too, though, Marie was a little like her sister, Alexandra, in that her love for her son was somewhat possessive. Also, as her husband was dying, she, in her grief, did not perhaps realize that Nicholas should have been more involved in the affairs of state (& that the medical bulletins should be brought directly to him). Coming in as an 'outsider' Alix saw this more clearly than those directly involved.
Then, the rushed wedding & the necessity of living with her mother-in-law meant that Alix & MF didn't 'get off to a good start.'
I believe that Alix was very unsure of her position when she was so suddenly thrust into role of Tsarina &, with MF still clinging to her status, Alix may have felt it necessary to stand her ground, which led to further, if unspoken, animosity between the two women.
I agree with you, Michael, 'no party was totally blameless' but equally no party was wholly responsible for the rift.
Had either of them been a little more flexible, it would have been mutually beneficial.