Maria Luisa Gabriela was the first queen of the Bourbons' branch settled in Spain, and also the mother of two kings. She was the third daughter of Anne Marie d'Orléans to her husband, Victor Amadeus II of Savoy. Through her mother, she was a grand-daughter of "Monsieur d'Orléans", Philippe, younger brother of Louis XIV, and his first wife, Henriette Anne of England.
When Maria Luisa Gabriela was just nine years old, her older sister Marie Adelaide was married to the French prince Louis, duke of Bourgogne. Only three years later, she found herself married to Philippe, duke of Anjou, younger brother of Louis. The marriage of Philippe, later Felipe V of Spain, and Maria Luisa Gabriela was a successful one. Maria Luisa proved she was born to become a great queen in the years of the ruinous War of Spanish Succesion. She was strong and energetic enough to gain the sympathy of the people of Madrid.