Minette had a hunchback, which was so slight that she could successfully hide it most of the time with carefully cut clothes. Henrietta Maria had a hunchback as well.
James I and Charles I had very thin, weak legs. Charles I couldn't walk unaided until he was four, while James also had problems walking throughout his life. There is no evidence that other members of the family had problems with their legs in childhood like those of James and Charles.
Both Charles I and James II stuttered. While in exile in France, Charles II reportedly stuttered as well, probably from stress.
Poor William of Gloucester suffered from hydrocephalus. In early childhood, he was already wearing adult-sized hats. His parents, in an effort to force him to overcome his difficulties in walking and climbing stairs, had him beaten, which naturally did no good. William's legs were fine; it was his oversized head that was the problem.