Isabelle, born 5th September 1451 at Warwick Castle, married George Duke of Clarence on 11th July at the Church of Our Lady, Calais 1469. They had four children, two of which survived childhood- Edward Earl of Warwick and Margaret Countess of Salisbury.
Isabelle died in December 1476 and is buried in Tewkesbury Abbey.
Anne,born 11th June 1456 at Warwick Castle. She married firstly, Edward Prince of Wales, son of Henry VI in 1470 and secondly, Richard Duke of Gloucester, the future Richard III,on 12th July 1472,in Westminster Abbey. Together they had a son Edward, who died aged 11 years old. Anne herself died in 1485.