Well Anne was a very energic woman. Strong character, very manly in her way of thinking and both a great politician and military strategist.
She was a mother for the first time when she was just 14, and she lost this child, her son Charles, when he died in 1498, aged 22. Her daughter Suzanne, born in 1491, 15 years after her brother, would also die young, in 1518. Of the three sons Suzanne had with the Duke Charles de Bourbon, none survived the first months,so when Anne died in 1522 she had survived her husband, all of her siblings and all of her descendants and nephews and nieces!!