Hemophilia carrier?

[Robby]

Hey everyone (thanks too look at my topic) i'm bizzy with a book about Maria Romanov, but now i have a question i read in a topic that Maria was a carrier of hemofilia? Is this true?

[Finelly]

No, we don't know if any of the girls were carriers.  Alexandra was a carrier.  Her mother was a carrier, but not all of Alice's daughters appeared to have carried the gene.

Only blood tests would show that, and none were performed.  Or, in the alternative, we could have known if the daughters had children and one or more sons had the disease.

[Georgiy]

All may have been carriers, then again none may have been, half of them, one or three of them. To make a bad pun, it is like Russian Roulette, and you don't even know if you are a carrier (at least in those days) until you have a haemophillac son (I think if you are a carrier it's 50% chance a son will be a sufferer but please correct me if I am wrong.)

[KentKim]

Carrier Mother + Normal Father
Each pregnancy has a 25% chance of resulting in a normal female, a 25% chance of resulting in a female carrier, a 25% chance of resulting in a normal male, and a 25% chance of resulting in a male with hemophilia.

Here: this may help
http://www.hemophiliagalaxy.com/patients/about/whogets/genetics.html

The interesting thing is that since Alexei had hemophilia, if he had survived (the revolution and the disease) to father children, all of his daughters would have been carriers, but none of his sons would be affected with it.

[lovy]

Just because Alexandra carried the disease, doesn't mean ALL of her daughters carried it, too. And if you're a haemophiliac carrier and you have a sons, it doesn't mean ALL of them have the disease. But I think definitely some of the GDs carried haemophilia/all of them. There is very little chance that NONE of them carried it.

[Romanov_fan]

It is true that it is unlikely none of them carried it although we don't know who did or didn't.

[lovy]

It could be possible that none of them were haemophiliac carriers - but I VERY much doubt it.

[Romanov_fan]

Yes, that is true, it is unlikely. But neither of Queen Ena of Spain's two daughters carried it, although their mother did, and if neither of them had never had children, someone would be sure one of them carried hemophilia.

[RomaFan96]

DNA testing on the IF's remains show that one of the younger girls. either Maria or Anastasia were carriers (it was either the youngest girl identified in 1991 who was presumed to Anastasia, or the girl found in 2007 whom the Russians have identified as Maria). Remember, Maria bled abnormally during an operation which could be a sign that she was a carrier. We'll never know for certain which GD was a carrier, but science has proved that one of them definitely had the gene.

[Kalafrana]

To complicate matters, a carrier mother will not pass the gene to all her children. So she may have sons who are not haemophiliacs, and daughters who are not carriers. Then a carrier daughter may have helathy sons, or no sons at all, but pass the gene to a daughter.

I have read a suggestion that VMH was a carrier, and passed the gene on to her daughter Alice, and through several generations of daughters, so that there is a hamophiliac among her descendants, but unfortunately I can't remember when I saw it or who the alleged haemophiliac is.

Ann

[edubs31]

Is there any evidence, through modern science, to suggest that there is a higher instance of hemophilia in unborn / stillborn babies? In other words does being effected by the Hemophilia gene also mean a greater likelihood that the fetus will die before it develops fulyl? A miscarriage being the result.

[Rodney_G.]

Carrier Mother + Normal Father
Each pregnancy has a 25% chance of resulting in a normal female, a 25% chance of resulting in a female carrier, a 25% chance of resulting in a normal male, and a 25% chance of resulting in a male with hemophilia.

Here: this may help
http://www.hemophiliagalaxy.com/patients/about/whogets/genetics.html

The interesting thing is that since Alexei had hemophilia, if he had survived (the revolution and the disease) to father children, all of his daughters would have been carriers, but none of his sons would be affected with it.

Is this last sentence true? Hemophilia is transmitted through the  female line, but males actually can have it , like Alexei. But do male hemophiliacs, like Alexei, necessarily pass it along to their offspring of either sex? And this is assuming the male hemophiliiac's partner/wife was hemophilia-free. What's the genetics of this?

[Kalafrana]

Haemophilia involves a defect on the X chromosome. Females, being XX, invariably transmit an X chromosome to offspring of either sex (which may or may not be the defective one). Males are XY, and transmit their X chromosome to their daughters and Y chromosome to their sons. If their X chromosome has the haemophilia gene, then it will inevitably pass to their daughters. Their sons get the healthy Y chromosome and so are unaffected.

In extremely rare cases, a haemophiliac father can have a child with a carrier mother, and produce a haemophiliac daughter.

Ann